Enzyme Immunoassay for the Quantitative Determination of Lp-PLA2 in Human Plasma and Serum FOR IN VITRO DIAGNOSTIC USE

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چکیده

Lp-PLA2 is a calcium-independent serine lipase that is associated with low-density lipoprotein (LDL) in human plasma and serum [1] and is distinct from other phospholipases such as cPLA2 and sPLA2 [2]. LpPLA2 is produced by macrophages and is expressed in greater concentrations in atherosclerotic lesions [3]. Several lines of evidence suggest that oxidation of LDL plays a critical step in the development and progression of atherosclerosis [4,5]. Lp-PLA2 participates in the oxidative modification of LDL by hydrolyzing oxidized phosphatidylcholines, generating lysophosphatidylcholine and oxidized free fatty acids, both of which are potent proinflammatory products that contribute to the formation of atherosclerotic plaques [6,7,8].

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تاریخ انتشار 2006